Structure–activity relationships of antityrosinase and antioxidant activities of cinnamic acid and its derivatives

ABSTRACT The related structure–activity relationships of cinnamic acid and its derivates have not been studied in details yet. Herein, antityrosinase antioxidant activities 18 compounds were evaluated. results demonstrated that the substituents on phenyl ring led to enhancement inhibition monophenolase weakening diphenolase. Among these tested compounds, 9 was first discovered as a tyrosinase inhibitor reversible competitive manner with IC50 value 68.6 ± 4.2 µm. Docking located into catalytic center tyrosinase. Antioxidant assay indicated only 1 hydroxyl group enough possess radical scavenging activity, number groups may be more important. This study will helpful development new inhibitors antioxidants higher efficacy.